Recombinant Human PKP1 protein, His & GST-tagged

• Cat.No.: PKP1-1975H
• Product Overview: Recombinant Human PKP1 aa. (Asn500~Asn742 (Accession # Q13835)) fused with N-terminal His & GST tag was produced in E. coli cells.

Specification

• Species: Human
• Source: E.coli
• Tag: GST&His
• Protein Length: Asn500~Asn742
• Description: This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may be involved in molecular recruitment and stabilization during desmosome formation. Mutations in this gene have been associated with the ectodermal dysplasia/skin fragility syndrome. Two transcript variants encoding different isoforms have been found for this gene.
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 58.8kDa
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: > 95%
• Characteristic: The isoelectric point is 8.4.
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage Buffer: Supplied as liquid form in Phosphate buffered saline(PBS), pH 7.4.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.

Gene Information

• Gene Name: PKP1 plakophilin 1 [ Homo sapiens (human) ]
• Official Symbol: PKP1
• Synonyms: Cyp24a1; cytochrome P450, family 24, subfamily a, polypeptide 1; CP24; Cyp24; 24-OHase; 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; 25-hydroxyvitamin D-24-hydroxylase; cytochrome P450 24A1; cytochrome P450, 24; cytochrome P450, 24a1; cytochrome P450-CC24; vitamin D(3) 24-hydroxylase
• Gene ID: 5317
• mRNA Refseq: NM_000299.3
• Protein Refseq: NP_000290.2
• UniProt ID: Q13835