Recombinant Human PKM2, His-tagged

• Cat.No.: PKM2-31019TH
• Product Overview: Recombinant full length Human PKM2 with an N-terminal hexahistidine tag

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported.
• Conjugation: HIS
• Tissue specificity: Specifically expressed in proliferating cells, such as embryonic stem cells, embryonic carcinoma cells, as well as cancer cells.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 50% Glycerol, 20mM Tris, pH 8
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the pyruvate kinase family.

Gene Information

• Gene Name: PKM2 pyruvate kinase, muscle [ Homo sapiens ]
• Official Symbol: PKM2
• Synonyms: PKM2; pyruvate kinase, muscle; pyruvate kinase isozymes M1/M2; OIP3; PK3; THBP1
• Gene ID: 5315
• mRNA Refseq: NM_001206796
• Protein Refseq: NP_001193725
• MIM: 179050
• Uniprot ID: P14618
• Chromosome Location: 15q22-qter
• Pathway: Glucose metabolism, organism-specific biosystem; Glycolysis, organism-specific biosystem; Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate, organism-specific biosystem; Glycolysis (Embden-Meyerhof pathway), glucose =>
• Function: ATP binding; magnesium ion binding; nucleotide binding; potassium ion binding; protein binding