Recombinant Human PKM Protein

• Cat.No.: PKM-4916H
• Product Overview: Recombinant human PKM Protein without tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Description: Pyruvate kinase isoform M2 (PKM2) is a member of the pyruvate kinase (PK) family, a pivotal glycolytic enzyme that is consistently changed during tumorigenesis. PKM2 is expressed in some differentiated tissues, such as lung, fat tissue, retina, and pancreatic islets. As the rate-controlling enzyme in glycolysis, PKM2, has also been found to be expressed in embryonic, proliferating, and tumor cells, and it has been considered to be crucial for the metabolism and growth of tumor cells. Recent studies have shown that PKM2 promotes cell proliferation and suppresses cell apoptosis in various tumors. In addition, it has been reported that the PKM2 knockdown affects the Akt and ERK protein kinases.
• Form: Lyophilized powder/frozen liquid
• Purity: >90% as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: PKM pyruvate kinase, muscle [ Homo sapiens (human) ]
• Official Symbol: PKM
• Synonyms: PK3; TCB; OIP3; PKM2; CTHBP; THBP1
• Gene ID: 5315
• mRNA Refseq: NM_182471
• Protein Refseq: NP_872271
• MIM: 179050
• UniProt ID: P14618