Recombinant Human PHLPP2, GST-tagged

• Cat.No.: PHLPP2-1615H
• Product Overview: Recombinant human PHLPP2 (766-1043) was expressed in E. coli cells using an N-terminal GST tag.

Specification

• Description: PHLPP2 or PH domain and leucine rich repeat protein phosphatase 2 is the important regulators of Akt serine-threonine kinases and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 differentially regulated AKT signaling by selectively dephosphorylating the hydrophobic motifs of AKT2 or AKT3. PHLPP may act as a tumor suppressor in several types of cancer due to its ability to block growth factor-induced signaling in cancer cells.
• Source: E.coli
• Species: Human
• Tag: GST
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Molecular Mass: ~ 56 kDa
• Protein length: 766-1043
• Purity: >95%
• Applications: Phosphatase Assay; Western Blot
• Stability: 1 yr at -70oC from date of shipment.
• Storage: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1 ug/ul

Gene Information

• Gene Name: PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 [ Homo sapiens ]
• Official Symbol: PHLPP2
• Synonyms: PHLPP2; PH domain and leucine rich repeat protein phosphatase 2; PH domain and leucine rich repeat protein phosphatase like , PHLPPL; PH domain leucine-rich repeat-containing protein phosphatase 2; KIAA0931; PHLPPL
• Gene ID: 23035
• mRNA Refseq: NM_015020
• Protein Refseq: NP_055835
• MIM: 611066
• UniProt ID: Q6ZVD8
• Chromosome Location: 16q22.2
• Pathway: Adaptive Immune System; DAP12 signaling; Downstream signaling events of B Cell Receptor (BCR); Downstream signaling of activated FGFR
• Function: metal ion binding; protein serine/threonine phosphatase activity