Recombinant Human PHLPP2, GST-tagged

• Cat.No.: PHLPP2-7012H
• Product Overview: Recombinant human PHLPP2 (766-1043) was expressed in E. coli cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 766-1043 aa
• Description: PHLPP2 or PH domain and leucine rich repeat protein phosphatase 2 is the important regulators of Akt serine-threonine kinases and conventional/novel protein kinase C (PKC) isoforms.PHLPP1 and PHLPP2 differentially regulated AKT signaling by selectively dephosphorylating the hydrophobic motifs of AKT2 or AKT3. PHLPP may act as a tumor suppressor in several types of cancer due to its ability to block growth factor-induced signaling in cancer cells.
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Molecular Mass: ~ 56 kDa
• Purity: >95%
• Applications: Phosphatase Assay, Western Blot
• Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
• Concentration: 0.1μg/μl

Gene Information

• Gene Name: PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 [ Homo sapiens ]
• Official Symbol: PHLPP2
• Synonyms: PHLPP2; PH domain and leucine rich repeat protein phosphatase 2; PH domain and leucine rich repeat protein phosphatase like , PHLPPL; PH domain leucine-rich repeat-containing protein phosphatase 2; KIAA0931; PHLPPL
• Gene ID: 23035
• mRNA Refseq: NM_015020
• Protein Refseq: NP_055835
• MIM: 611066
• UniProt ID: Q6ZVD8
• Chromosome Location: 16q22.2
• Function: hydrolase activity; metal ion binding; phosphoprotein phosphatase activity