Recombinant Human Peptidyl-TRNA Hydrolase 2, 64-179 aa, His-tagged

• Cat.No.: PTRH2-3370H
• Product Overview: Recombinant human PTRH2 protein was expressed inE.coliand purified by using conventional chromatography techniques. MW = 14.9 kDa (137aa).

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: PTRH2 (peptidyl-tRNA hydrolase 2), also known as BIT1, is a mitochondrial protein. During apoptosis, PTRH2 is released from the mitochondria to the cytoplasm. Once in the cytoplasm, PTRH2 regulates the function of two transcriptional regulators, TLE5 and TLE1, thereby promoting caspase-independent cell death. The natural substrate for PTRH2 may be petidyl-tRNAs which drop off the ribosome during protein synthesis.
• Form: Liquid. In 20mM Tris buffer (pH 8.0) containing 10% glycerol, 1mM DTT.
• Purity: > 95% by SDS - PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MEYKMILVVR NDLKMGKGKV AAQCSHAAVS AYKQIQRRNP EMLKQWEYCG QPKVVVKAPD EETLIALLAH AKMLGLTVSL IQDAGRTQIA PGSQTVLGIG PGPADLIDKV TGHLKLY.
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: PTRH2 peptidyl-tRNA hydrolase 2 [ Homo sapiens ]
• Synonyms: peptidyl-tRNA hydrolase 2; BIT1; PTH2; CGI-147; FLJ32471; PTRH2; peptidyl-tRNA hydrolase 2, mitochondrial; PTH 2; OTTHUMP00000205936; bcl-2 inhibitor of transcription 1; Bcl-2 inhibitor of transcription 1
• Gene ID: 51651
• mRNA Refseq: NM_016077
• Protein Refseq: NP_057161
• MIM: 608625
• UniProt ID: Q9Y3E5
• Chromosome Location: 17q23.1
• Function: aminoacyl-tRNA hydrolase activity; hydrolase activity