Recombinant Human PDXP, His-tagged

• Cat.No.: PDXP-30082TH
• Product Overview: Recombinant full length Human PDXP with N terminal His tag; 316aa, 33.8kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 296 amino acids
• Description: Pyridoxal 5-prime-phosphate (PLP) is the active form of vitamin B6 that acts as a coenzyme in maintaining biochemical homeostasis. The preferred degradation route from PLP to 4-pyridoxic acid involves the dephosphorylation of PLP by PDXP (Jang et al.
• Conjugation: HIS
• Molecular Weight: 33.800kDa inclusive of tags
• Tissue specificity: Ubiquitous. Highly expressed in all the regions of central nerve system except the spinal cord. Also expressed at high level in liver and testis. In fetus, it is weakly expressed in all organs except brain.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMARCERLRGAALRDVLGRAQGVLFDCDGVLWNGERAVPGAPELLERLARAGKAALFVSNNSRRARPELALRFARLGFGGLRAEQLFSSALCAARLLRQRLPGPPDAPGAVFVLGGEGLRAELRAAGLRLAGDPSAGDGAAPRVRAVLVGYDEHFSFAKLREACAHLRDPECLLVATDRDPWHPLSDGSRTPGTGSLAAAVETASGRQALVVGKPSPYMFECITENFSIDPARTLMVGDRLETDILFGHRCGMTTVLTLTGVSRLEEAQAYLAAGQHDLVPHYYVESIADLTEGLED
• Sequence Similarities: Belongs to the HAD-like hydrolase superfamily.

Gene Information

• Gene Name: PDXP pyridoxal (pyridoxine, vitamin B6) phosphatase [ Homo sapiens ]
• Official Symbol: PDXP
• Synonyms: PDXP; pyridoxal (pyridoxine, vitamin B6) phosphatase; pyridoxal phosphate phosphatase; dJ37E16.5; FLJ32703
• Gene ID: 57026
• mRNA Refseq: NM_020315
• Protein Refseq: NP_064711
• MIM: 609246
• Uniprot ID: Q96GD0
• Chromosome Location: 22q12.3
• Pathway: Metabolic pathways, organism-specific biosystem; Vitamin B6 metabolism, organism-specific biosystem; Vitamin B6 metabolism, conserved biosystem
• Function: heat shock protein binding; hydrolase activity; metal ion binding; phosphoprotein phosphatase activity; phosphoserine phosphatase activity