Recombinant Human PDE8B
| Cat.No. : | PDE8B-30225TH |
| Product Overview : | Recombinant fragment of Human PDE8B with N-terminal proprietary tag, 115kDa. |
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| Description : | The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene. |
| Protein length : | 773 amino acids |
| Molecular Weight : | 115.000kDa inclusive of tags |
| Source : | Baculovirus infected sf9 cells |
| Tissue specificity : | Abundantly expressed in the thyroid. Also very weakly expressed in brain, spinal cord and placenta. In the thyroid isoform 1 predominates, and isoforms 2 and 6 are also highly expressed. In the placenta isoforms 1 and 2 are expressed equally. In the brain |
| Biological activity : | The Specific activity of PDE8B-30225TH was determined to be 40 nmol/min/mg. |
| Form : | Liquid |
| Purity : | by SDS-PAGE |
| Storage buffer : | Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5 |
| Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
| Sequence Similarities : | Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.Contains 1 PAS (PER-ARNT-SIM) domain. |
| Tag : | Non |
| Gene Name | PDE8B phosphodiesterase 8B [ Homo sapiens ] |
| Official Symbol | PDE8B |
| Synonyms | PDE8B; phosphodiesterase 8B; high affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8B; |
| Gene ID | 8622 |
| mRNA Refseq | NM_001029851 |
| Protein Refseq | NP_001025022 |
| MIM | 603390 |
| Uniprot ID | O95263 |
| Chromosome Location | 5q14.1 |
| Pathway | G Protein Signaling Pathways, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Purine metabolism, organism-specific biosystem; Purine metabolism, conserved biosystem; |
| Function | 3,5-cyclic-nucleotide phosphodiesterase activity; hydrolase activity; metal ion binding; phosphoric diester hydrolase activity; two-component response regulator activity; |
Not For Human Consumption!
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