Recombinant Human PDE4B Protein, His/GST-tagged

• Cat.No.: PDE4B-147H
• Product Overview: Recombinant human N-terminal His-GST-tagged PDE4B2 protein (1-564) was expressed in insect cells.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST&His
• Protein Length: 1-564
• Description: This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms.
• Form: Lyophilized
• Molecular Mass: 92.2 kDa
• Endotoxin: <1.0 EU/μg, determined by the LAL endotoxin assay
• Purity: ≥80% estimated by SDS-PAGE
• Stability: ≥ 1 year
• Storage: At -80 centigrade.
• Storage Buffer: Lyophilized from sterile 50 mM Tris, pH 8.0, with 100 mM sodium chloride, 0.5 mM GSH, 10% gly, and 0.5 mM PMSF

Gene Information

• Gene Name: PDE4B phosphodiesterase 4B [ Homo sapiens (human) ]
• Official Symbol: PDE4B
• Synonyms: PDE4B; phosphodiesterase 4B; DPDE4; PDEIVB; cAMP-specific 3',5'-cyclic phosphodiesterase 4B; dunce-like phosphodiesterase E4; phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila); EC 3.1.4.53
• Gene ID: 5142
• mRNA Refseq: NM_001037339
• Protein Refseq: NP_001032416
• MIM: 600127
• UniProt ID: Q07343