Recombinant Human PDE4B, GST-tagged

• Cat.No.: PDE4B-30819TH
• Product Overview: Recombinant full length PDE4B protein (Human) with an N terminal GST tag. MW 109kDa. Source: Baculovirus infected Sf9 cells.

Specification

• Species: Human
• Tag: GST
• Description: This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
• Conjugation: GST
• Tissue specificity: Expressed in brain, heart, lung and skeletal muscle.
• Biological activity: Specific Activity: 10000 U/μg.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 50% Glycerol, 0.05% Tween 20, 5mM Glutathione, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
• Full Length: Full L.

Gene Information

• Gene Name: PDE4B phosphodiesterase 4B, cAMP-specific [ Homo sapiens ]
• Official Symbol: PDE4B
• Synonyms: PDE4B; phosphodiesterase 4B, cAMP-specific; DPDE4, phosphodiesterase 4B, cAMP specific (dunce (Drosophila) homolog phosphodiesterase E4) , phosphodiesterase 4B, cAMP specific (phosphodiesterase E4 dunce homolog, Drosophila); cAMP-specific 3,5-cyclic pho
• Gene ID: 5142
• mRNA Refseq: NM_001037339
• Protein Refseq: NP_001032416
• MIM: 600127
• Uniprot ID: Q07343
• Chromosome Location: 1p31
• Pathway: DARPP-32 events, organism-specific biosystem; G Protein Signaling Pathways, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Myometrial Relaxation and Contraction Pathways, organism-specific biosystem
• Function: 3,5-cyclic-AMP phosphodiesterase activity; hydrolase activity; metal ion binding; phosphoric diester hydrolase activity