Recombinant Human PDE1C Protein, His/GST-tagged

• Cat.No.: PDE1C-047H
• Product Overview: Recombinant N-terminal His-GST-tagged full length human PDE1C1 protein (1-634) was expressed in insect cells.

Specification

• Description: This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta.
• Source: Insect cell
• Species: Human
• Tag: His&GST
• Form: Lyophilized
• Molecular Mass: 100 kDa
• Protein length: 1-634
• Endotoxin: <1.0 EU/ μg, determined by the LAL endotoxin assay.
• Purity: ≥85% estimated by SDS-PAGE
• Stability: ≥ 6 months
• Storage: At -80 centigrade.
• Storage Buffer: Sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10% glycerol, 3 mM DTT

Gene Information

• Gene Name: PDE1C phosphodiesterase 1C [ Homo sapiens (human) ]
• Official Symbol: PDE1C
• Synonyms: PDE1C; phosphodiesterase 1C; Hcam3; DFNA74; hCam-3; cam-PDE 1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C; 3',5'-cyclic-AMP phosphodiesterase; 3',5'-cyclic-GMP phosphodiesterase; Human 3',5' cyclic nucleotide phosphodiesterase (HSPDE1C1A); phosphodiesterase 1C, calmodulin-dependent 70kDa; EC 3.1.4.35
• Gene ID: 5137
• mRNA Refseq: NM_005020
• Protein Refseq: NP_005011
• MIM: 602987
• UniProt ID: Q8TAE4