Recombinant Human PDE1C Protein, His/GST-tagged

• Cat.No.: PDE1C-03H
• Product Overview: Recombinant human PDE1C protein (1-634) with a N-teminus His/GST-tag was expressed in insect cells.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST&His
• Protein Length: 1-634
• Description: This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta.
• Form: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10% glycerol, 3 mM DTT
• Molecular Mass: 100 kDa
• Endotoxin: <1.0 EU/μg of the protein as determined by the LAL method
• Purity: ≥85 % as determined by SDS-PAGE
• Stability: ≥ 1 year
• Storage: Store at -80 centigrade

Gene Information

• Gene Name: PDE1C phosphodiesterase 1C [ Homo sapiens (human) ]
• Official Symbol: PDE1C
• Synonyms: PDE1C; phosphodiesterase 1C; Hcam3; DFNA74; hCam-3; cam-PDE 1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C; 3',5'-cyclic-AMP phosphodiesterase; 3',5'-cyclic-GMP phosphodiesterase; Human 3',5' cyclic nucleotide phosphodiesterase (HSPDE1C1A); phosphodiesterase 1C, calmodulin-dependent 70kDa
• Gene ID: 5137
• mRNA Refseq: NM_001191056
• Protein Refseq: NP_001177985
• MIM: 602987
• UniProt ID: Q14123