Recombinant Human PCSK9 Protein, His\HA\Avi-tagged

• Cat.No.: PCSK9-206H
• Product Overview: Biotinylated Recombinant Human Proprotein Convertase Subtilisin/Kexin Type 9 is produced by our Mammalian expression system and the target gene encoding Gln31-Gln692(Val474Ile,Gly670Glu) is expressed with a 8His, HA, Avi tag at the C-terminus.

Specification

• Species: Human
• Source: Human Cells
• Tag: Avi&HA&His
• Protein Length: 31-692 a.a.
• Description: Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2), and play a role in the neural development.
• Form: Supplied as a 0.2 um filtered solution of 50mM HEPES, 150mM NaCl, 20% Glycerol, pH 7.4.
• Molecular Mass: Predicted Molecular Weight: 14&62kDa
  Apparent Molecular Weight: 18&58-70&90-150kDa, reducing conditions.
• AA Sequence: Gln31-Gln692(Val474Ile,Gly670Glu)
• Endotoxin: Less than 0.1 ng/ug (1 EU/ug).
• Purity: >95%
• Storage: Store at < -20 centigrade, stable for 6 months after receipt.
  Please minimize freeze-thaw cycles.
• Quality Statement: Purity: greater than 95% as determined by reducing SDS-PAGE.
• Shipping: The product is shipped at ambient temperature.
  Upon receipt, store it immediately at the temperature listed below.

Gene Information

• Gene Name: PCSK9 proprotein convertase subtilisin/kexin type 9 [ Homo sapiens (human) ]
• Official Symbol: PCSK9
• Synonyms: Proprotein Convertase Subtilisin/Kexin Type 9; Neural Apoptosis-Regulated Convertase 1; NARC-1; Proprotein Convertase 9; PC9; Subtilisin/Kexin-Like Protease PC9; NARC1; FH3; PC9; FHCL3; LDLCQ1; HCHOLA3
• Gene ID: 255738
• mRNA Refseq: NM_001407240.1
• Protein Refseq: NP_001394169.1
• MIM: 607786
• UniProt ID: Q8NBP7