Recombinant Human PARK2 protein, His-tagged

• Cat.No.: PARK2-11H
• Product Overview: Recombinant Human PARK2 protein was fused to His-tag and expressed in human 293 cells (HEK293).

Specification

• Species: Human
• Source: HEK293
• Tag: His
• Description: The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.
• Form: Sterile PBS, pH 7.4
• Molecular Mass: ~ 52 kDa
• Endotoxin: <1 EU per ug (determined by the LAL method)
• Purity: ≥ 85% as determined by SDS-PAGE.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Concentration: 0.28 mg/ml

Gene Information

• Gene Name: PRKN
• Official Symbol: PRKN
• Synonyms: PDJ; AR-JP; LPRS2; PARK2
• Gene ID: 5071
• mRNA Refseq: NM_004562.3
• Protein Refseq: NP_004553.2
• MIM: 602544
• UniProt ID: O60260