Recombinant Human PARD6B, His-tagged

Cat.No. : PARD6B-7058H
Product Overview : Recombinant human PARD6B protein, fused to His-tag at N-terminus, was expressed in E.coli.
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Species : Human
Source : E.coli
Tag : His
Protein Length : 1-372aa
Description : Partitioning defective 6 homolog beta, also known as PARD6B, is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. Cellular asymmetry is critical for the development of multicellular organisms. PARD (partitioning-defective) proteins play important roles in asymmetric cell division and polarized growth, whereas Cdc42 and Rac mediate establishment of cell growth and polarity and contribute to oncogenic transformation by Ras. It is expressed in pancreas and in both adult and fetal kidney, and is weakly expressed in placenta and lung.
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 2M Urea, 20% glycerol, 0.2M NaCl
Molecular Mass : 43.6 kDa (395aa)
AA Sequence : MGSSHHHHHH SSGLVPRGSH MGSMNRSHRH GAGSGCLGTM EVKSKFGAEF RRFSLERSKP GKFEEFYGLL QHVHKIPNVD VLVGYADIHG DLLPINNDDN YHKAVSTANP LLRIFIQKKE EADYSAFGTD TLIKKKNVLT NVLRPDNHRK KPHIVISMPQ DFRPVSSIID VDILPETHRR VRLYKYGTEK PLGFYIRDGS SVRVTPHGLE KVPGIFISRL VPGGLAQSTG LLAVNDEVLE VNGIEVSGKS LDQVTDMMIA NSRNLIITVR PANQRNNVVR NSRTSGSSGQ STDNSLLGYP QQIEPSFEPE DEDSEEDDII IEDNGVPQQI PKAVPNTESL ESLTQIELSF ESGQNGFIPS NEVSLAAIAS SSNTEFETHA PDQKLLEEDG TIITL
Purity : >85% by SDS - PAGE
Applications : SDS-PAGE
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Concentration : 0.5 mg/ml
Gene Name PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) [ Homo sapiens ]
Official Symbol PARD6B
Synonyms PARD6B; par-6 partitioning defective 6 homolog beta (C. elegans); par 6 (partitioning defective 6, C.elegans) homolog beta; partitioning defective 6 homolog beta; PAR 6B; PAR-6 beta; PAR6B;
Gene ID 84612
mRNA Refseq NM_032521
Protein Refseq NP_115910
MIM 608975
UniProt ID Q9BYG5
Chromosome Location 20q13.13
Pathway Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Cell-cell junction organization, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Tight junction, organism-specific biosystem; Tight junction, conserved biosystem;
Function protein binding;

Not For Human Consumption!

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