Recombinant Human PAK6, GST-tagged, Active

• Cat.No.: PAK6-381H
• Product Overview: Recombinant full-length human PAK6 was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=110 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: PAK6 is a Ser/Thr protein kinase that is a member of the PAK (p21-activated kinase) family that are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. PAK6 is highly expressed in the testis and prostate tissues and interacts with the androgen receptor (AR). In response to androgen, PAK6 cotranslocate into the nucleus with AR. PAK6 is weakly expressed in normal prostate epithelium but the expression is increased in primary and metastatic prostate cancer cells and is further increased in tumors that relapse after androgen deprivation therapy.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: PAK6 p21 protein (Cdc42/Rac)-activated kinase 6 [ Homo sapiens ]
• Synonyms: PAK6; p21 protein (Cdc42/Rac)-activated kinase 6; PAK5; p21-activated kinase 6; p21(CDKN1A)-activated kinase 6; p21-activated protein kinase 6; EC 2.7.11.1
• Gene ID: 56924
• mRNA Refseq: NM_001128628
• Protein Refseq: NP_001122100
• MIM: 608110
• UniProt ID: Q9NQU5
• Chromosome Location: 15q14
• Pathway: Axon guidance; ErbB signaling pathway; Focal adhesion; Regulation of actin cytoskeleton; Renal cell carcinoma; T cell receptor signaling pathway
• Function: ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity