Recombinant Human PADI3 Protein, His-tagged

• Cat.No.: PADI3-122H
• Product Overview: Active human recombinant N-terminal His-tagged full length human PAD3 protein (2-664) was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 2-664
• Description: This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type III enzyme modulates hair structural proteins, such as filaggrin in the hair follicle and trichohyalin in the inner root sheath, during hair follicle formation. Together with the type I enzyme, this enzyme may also play a role in terminal differentiation of the epidermis. This gene exists in a cluster with four other paralogous genes.
• Molecular Mass: 76.4 kDa
• Purity: ≥85% estimated by SDS-PAGE
• Unit Definition: One unit is defined as the amount of enzyme required to produce 1 nmol of NH4+ per minute at 37 centigrade in 50 mM HEPES, pH 7.7, containing 10 mM calcium chloride, 5 mM DTT, and 4 mM N-α-Benzoyl-L-Arginineethylester(BAEE).
• Stability: ≥ 2 years
• Storage: At -80 centigrade.
• Storage Buffer: 50 mM HEPES, pH 8.0, containing 300 mM sodium chloride, 1 mM DTT, and 10% glycerol

Gene Information

• Gene Name: PADI3 peptidyl arginine deiminase 3 [ Homo sapiens (human) ]
• Official Symbol: PADI3
• Synonyms: PADI3; peptidyl arginine deiminase 3; PAD3; PDI3; UHS1; protein-arginine deiminase type-3; peptidyl arginine deiminase, type III; peptidylarginine deiminase III; protein-arginine deiminase type III; EC 3.5.3.15
• Gene ID: 51702
• mRNA Refseq: NM_016233
• Protein Refseq: NP_057317
• MIM: 606755
• UniProt ID: Q9ULW8