Recombinant Human OTX2 protein, T7/His-tagged

• Cat.No.: OTX2-193H
• Product Overview: Recombinant human OTX2 (2 - 297 aa, Isoform-I, derived from BC032579) fused with T7-His-TEV cleavage site Tag at N-terminal was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: His&T7
• Form: 0.25 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose and DTT.
• AA Sequence: MASMTGGQQMGRGHHHHHHENLYFQ GEFMSYLKQPPYAVNGLSLTTSGMD LLHPSVGYPGPWASCPAATPRKQRR ERTTFTRAQLDVLEALFAKTRYPDI FMREEVALKINLPESRVQVWFKNRR AKCRQQQQQQQNGGQNKVRPAKKKT SPAREVSSESGTSGQFTPPSSTSVP TIASSSAPVSIWSPASISPLSDPLS TSSSCMQRSYPMTYTQASGYSQGYA GSTSYFGGMDCGSYLTPMHHQLPGP GATLSPMGTNAVTSHLNQSPASLST QGYGASSLGFNSTTDCLDYKDQTAS WKLNFNADCLDYKDQTSSWKFQVL
• Purity: >90% by SDS-PAGE
• Storage: Keep at -80 centigrade for long term storage. Product is stable at 4 centigrade for at least 7 days.
• Protein length: 2-297

Gene Information

• Gene Name: OTX2 orthodenticle homeobox 2 [ Homo sapiens ]
• Official Symbol: OTX2
• Synonyms: OTX2; orthodenticle homeobox 2; orthodenticle homolog 2 (Drosophila); homeobox protein OTX2; orthodenticle homolog 2; CPHD6; MCOPS5; MGC45000
• Gene ID: 5015
• mRNA Refseq: NM_021728
• Protein Refseq: NP_068374
• MIM: 600037
• UniProt ID: P32243
• Chromosome Location: 14q22.3
• Function: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; eukaryotic initiation factor 4E binding; protein binding; sequence-specific DNA binding; sequence

Reviews

02/18/2023

The OTX2 protein is of exceptional quality, meeting all my experimental requirements with precision and reliability.

06/05/2020

This dedication ensures that I have access to the most advanced and reliable protein in my studies, enhancing the overall quality and impact of my research outcomes.

06/11/2018

This exceptional level of support enables me to overcome challenges efficiently and progress smoothly with my research.

Q&As

Are there any specific drugs targeting OTX2 currently in development?

As of my last knowledge update, there were no specific drugs targeting OTX2 in advanced stages of development, but ongoing research might uncover potential drug candidates.

Can OTX2 be a target for gene therapy?

Yes, gene therapy targeting the OTX2 gene is being investigated as a potential approach for treating disorders related to OTX2 dysfunction.

Can alterations in OTX2 expression be detected through diagnostic tests?

While not yet widely used in clinical practice, diagnostic tests assessing OTX2 expression levels may become relevant in the future for certain developmental and neurological disorders.

How is OTX2 relevant to cancer research?

OTX2 has been implicated in certain types of brain tumors, and understanding its role in cancer may provide insights into potential targeted therapies.

Are there any ongoing clinical trials involving OTX2?

As of my last knowledge update in January 2022, specific clinical trials involving OTX2 were not widely reported. However, ongoing research may have progressed since then.