OTX2
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Official Full Name
orthodenticle homeobox 2 -
Overview
OTX2 (Orthodenticle homeobox 2) belongs to the bicoid subfamily of paired-box, homeodomain-containing transcription factors. OTX2 is a critically important neuronal transcription factor that functions to regulate the expression of cell cycle genes control -
Synonyms
OTX2;orthodenticle homeobox 2;orthodenticle homolog 2 (Drosophila);homeobox protein OTX2;orthodenticle homolog 2;CPHD6;MCOPS5;MGC45000
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Non
- His&T7
- His
- His&SUMO
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| OTX2-165H | Recombinant Human OTX2 | E.coli | Human | Non | 1-297 a.a. |
|
| OTX2-193H | Recombinant Human OTX2 protein, T7/His-tagged | E.coli | Human | His&T7 | 2-297 a.a. |
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| OTX2-25H | Recombinant Human OTX2 Protein, His-tagged | E.coli | Human | His |
|
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| OTX2-26H | Recombinant Human OTX2 Protein, His-tagged | E.coli | Human | His | Full L. |
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| OTX2-390H | Recombinant Human OTX2 Protein, His-tagged | E.coli | Human | His |
|
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| OTX2-6089C | Recombinant Chicken OTX2 | Mammalian Cell | Chicken | His |
|
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| OTX2-8848Z | Recombinant Zebrafish OTX2 | Mammalian Cell | Zebrafish | His |
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| OTX2-3511HCL | Recombinant Human OTX2 293 Cell Lysate | HEK293 | Human | Non |
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| OTX2-3310H | Recombinant Human OTX2 protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 1-297aa |
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| Otx2-3311M | Recombinant Mouse Otx2 protein, His-tagged | E.coli | Mouse | His | 1-289aa |
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| OTX2-4776H | Recombinant Human OTX2 Protein (Met1-Leu297), C-His tagged | E.coli | Human | His | Met1-Leu297 |
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Involved Pathway
OTX2 involved in several pathways and played different roles in them. We selected most pathways OTX2 participated on our site, such as TP53 network, which may be useful for your reference. Also, other proteins which involved in the same pathway with OTX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TP53 network | BOK |
Protein Function
OTX2 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,eukaryotic initiation factor 4E binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by OTX2 itself. We selected most functions OTX2 had, and list some proteins which have the same functions with OTX2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | DDN,MIXL1,AEBP2,ZFP746,FOXI1,ZFP536,TFAP2A,ETS2,EBF1,PITX3 |
| protein binding | ALPI,FAM83A,FAM168A,TIMM23,AF251705,KLHL7,RBM10,SYN1,C4BPB,SLC6A4 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | TFAM,ZIC3,ONECUT3,NPAS4,TFAP4,PAX8,MEIS1,FOXC2,FIGLA,MYB |
| eukaryotic initiation factor 4E binding | EIF4EBP2,EIF4G1,EIF4EBP3,HHEX,EIF4EBP1,GRA,EIF4EBP3L,ANGEL1,DDX3X,LARP1 |
Interacting Protein
OTX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OTX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of OTX2.
ATXN1;HBZ;CDK4
Resources
Research Area
Early Ectodermal Lineage MarkersNeural Stem Cell Markers
Pluripotent Stem Cell Transcription Factors
Ectodermal Lineage Markers
Related Services
Related Products
References
- Tang, JCY; Szikra, T; et al. A Nanobody-Based System Using Fluorescent Proteins as Scaffolds for Cell-Specific Gene Manipulation. CELL 154:928-939(2013).
- Reers, S; Pfannerstill, AC; et al. Stem cell profiling in head and neck cancer reveals an Oct-4 expressing subpopulation with properties of chemoresistance. ORAL ONCOLOGY 50:155-162(2014).
