Recombinant Human OSTM1 protein, His & T7-tagged

• Cat.No.: OSTM1-8007H
• Product Overview: Recombinant Human OSTM1 aa. (Gln120~Gly251 (Accession # Q86WC4)) fused with N-terminal His & T7 tag was produced in E. coli cells.

Specification

• Species: Human
• Source: E.coli
• Tag: His&T7
• Protein Length: Gln120~Gly251
• Description: This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis.
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 18.6kDa
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >90%
• Characteristic: The isoelectric point is 5.3.
• Applications: SDS-PAGE; WB; ELISA; IP
• Stability: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage Buffer: Supplied as lyophilized form in 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.
• Reconstitution: Reconstitute in sterile ddH2O.

Gene Information

• Gene Name: OSTM1 osteopetrosis associated transmembrane protein 1 [ Homo sapiens (human) ]
• Official Symbol: OSTM1
• Synonyms: GL; GIPN; OPTB5; HSPC019; CLCN7 accessory beta subunit; GAIP-interacting protein N terminus; chloride channel 7 beta subunit; grey-lethal osteopetrosis; osteopetrosis-associated transmembrane protein 1
• Gene ID: 28962
• mRNA Refseq: NM_014028.3
• Protein Refseq: NP_054747.2
• UniProt ID: Q86WC4