Recombinant Human ORC1 Protein, GST-tagged

• Cat.No.: ORC1-01H
• Product Overview: Recombinant AH domain region of ORC1 protein with a N-terminal GST tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 2-185
• Description: The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Molecular Mass: 48.2 kDa
• Purity: ≥ 80%
• Stability: ≥ 6 months
• Storage: Store at -80 centigrade.
• Storage Buffer: 20 mM Tris, pH 8.0, with 50 mM sodium chloride and 20% glycerol
• Shipping: Dry ice in continental US; may vary elsewhere

Gene Information

• Gene Name: ORC1 origin recognition complex subunit 1 [ Homo sapiens (human) ]
• Official Symbol: ORC1
• Synonyms: ORC1; origin recognition complex subunit 1; ORC1L; PARC1; HSORC1; origin recognition complex subunit 1; origin recognition complex, subunit 1 homolog; replication control protein 1
• Gene ID: 4998
• mRNA Refseq: NM_004153
• Protein Refseq: NP_004144
• MIM: 601902
• UniProt ID: Q13415