Recombinant Human OAS2 Protein (Val11-His346), His tagged

• Cat.No.: OAS2-4755H
• Product Overview: Recombinant human OAS2 (Val11-His346) fused with His tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: Val11-His346
• Description: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Activated by detection of double stranded RNA (dsRNA) : polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation. Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates. Non-infected lobules would not be affected, allowing efficient pup feeding during infection.
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 38.71 kDa
• Purity: >90% as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: OAS2 2-5-oligoadenylate synthetase 2, 69/71kDa [ Homo sapiens (human) ]
• Official Symbol: OAS2
• Synonyms: OAS2; 2-5-oligoadenylate synthetase 2, 69/71kDa; 2 5 oligoadenylate synthetase 2 (69 71 kD); 2-5-oligoadenylate synthase 2; 2-5A synthase 2; p69 OAS / p71 OAS; (2-5) oligo (A) synthetase 2; MGC78578
• Gene ID: 4939
• mRNA Refseq: NM_001032731
• Protein Refseq: NP_001027903
• MIM: 603350
• UniProt ID: P29728