Recombinant Human OAS2 Protein, His-tagged

• Cat.No.: OAS2-309H
• Product Overview: Recombinant Human OAS2(Val11~His346) fused with His tag at N-terminal was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: Val11~His346
• Description: This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.
• Form: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Molecular Mass: 42.6kDa
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: > 98%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
  If bio-activity of the protein is needed, please check active protein.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: OAS2 2-5-oligoadenylate synthetase 2, 69/71kDa [ Homo sapiens ]
• Official Symbol: OAS2
• Synonyms: OAS2; 2-5-oligoadenylate synthetase 2, 69/71kDa; 2 5 oligoadenylate synthetase 2 (69 71 kD); 2-5-oligoadenylate synthase 2; 2-5A synthase 2; p69 OAS / p71 OAS; (2-5)oligo(A) synthetase 2; MGC78578
• Gene ID: 4939
• mRNA Refseq: NM_001032731
• Protein Refseq: NP_001027903
• MIM: 603350
• UniProt ID: P29728