Recombinant Human NUP98 cell lysate

• Cat.No.: NUP98-1235HCL

Specification

• Species: Human
• Tag: Non
• Description: Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kD precursor protein. This cleavage results in the 98 kD nucleoporin as well as a 96 kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: NUP98 nucleoporin 98kDa [ Homo sapiens ]
• Official Symbol: NUP98
• Synonyms: NUP98; nucleoporin 98kDa; nucleoporin 98kD; nuclear pore complex protein Nup98-Nup96; NUP96; Nup98-Nup96; GLFG-repeat containing nucleoporin; ADIR2; NUP196
• Gene ID: 4928
• mRNA Refseq: NM_005387
• Protein Refseq: NP_005378
• MIM: 601021
• UniProt ID: P52948
• Chromosome Location: 11p15
• Pathway: Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; DNA Replication, organism-specific biosystem; Disease, organism-specific biosystem; Export of Viral Ribonucleoproteins from Nucleus, organism-specific biosystem
• Function: protein binding; structural constituent of nuclear pore; transporter activity