Recombinant Human NUMB Protein, His-tagged

• Cat.No.: NUMB-235H
• Product Overview: Recombinant Human NUMB, transcript variant 1, fused with His tag at N-terminal was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.
• Form: 25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1% Sarkosyl.
• Molecular Mass: 70.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: NUMB numb homolog (Drosophila) [ Homo sapiens ]
• Official Symbol: NUMB
• Synonyms: NUMB; numb homolog (Drosophila); C14orf41, chromosome 14 open reading frame 41 , numb (Drosophila) homolog; protein numb homolog; h-Numb; S171; C14orf41; c14_5527; FLJ31314
• Gene ID: 8650
• mRNA Refseq: NM_001005743
• Protein Refseq: NP_001005743
• MIM: 603728
• UniProt ID: P49757