NUMB
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Official Full Name
numb homolog -
Overview
Numb contains an amino-terminal phosphotyrosine-binding (PTB) domain and carboxy-terminal endocytic binding motifs for alpha-adaptin and EH (Eps15 homology) domain-containing proteins, indicating a role in endocytosis. There are four mammalian Numb splici -
Synonyms
NUMB;numb homolog (Drosophila);C14orf41, chromosome 14 open reading frame 41 , numb (Drosophila) homolog;protein numb homolog;h-Numb;S171;C14orf41;c14_5527;FLJ31314
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Chicken
- E. coli
- Mammalian Cell
- E.coli
- Sf9 Insect Cell
- HEK293
- HEK293T
- Mammalian cells
- His
- Flag
- Non
- Myc&DDK
- His&Fc&Avi
- His&T7
Involved Pathway
NUMB involved in several pathways and played different roles in them. We selected most pathways NUMB participated on our site, such as Notch signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NUMB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Notch signaling pathway | DLK1,HDAC1,CTBP1,LFNG,APH1C,DTX3L,NOTCH1A,PSEN1,YY1,DLC |
Protein Function
NUMB has several biochemical functions, for example, alpha-catenin binding,beta-catenin binding,cadherin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NUMB itself. We selected most functions NUMB had, and list some proteins which have the same functions with NUMB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cadherin binding | FER,NDRG1,CD2AP,CTNNB1,PSEN1,P2RX4,JUP,FXYD5,TRPC4,CTNNA2 |
| protein binding | PBXIP1,TRPC3,NTS,THOC7,ITGB2,TBCA,CHCHD2,BIRC3,MLL1,RBM25 |
| beta-catenin binding | CXADR,ESR1,KDM6B,SOX9,KLF4,SOX17,PSEN1,LEF1,MED12,APC2 |
| alpha-catenin binding | CTNNB1,VCL,PKP2,AJUBA,JUB,JUPA,JUP,CDH2,PKP3,CDH24 |
Interacting Protein
NUMB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NUMB here. Most of them are supplied by our site. Hope this information will be useful for your research of NUMB.
EPS15;AP2M1;REPS1;FRS3;IRS1;LNX1;EGFR;APP
NUMB Related Signal Pathway
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References
- Yang, ML; Ye, L; et al. Decreased miR-146 expression in peripheral blood mononuclear cells is correlated with ongoing islet autoimmunity in type 1 diabetes patients. JOURNAL OF DIABETES 7:158-165(2015).
- Pasto, A; Serafin, V; et al. NOTCH3 Signaling Regulates MUSASHI-1 Expression in Metastatic Colorectal Cancer Cells. CANCER RESEARCH 74:2106-2118(2014).
