Recombinant Human NTS, His-tagged

• Cat.No.: NTS-7064H
• Product Overview: Recombinant human NTS protein, fused to His-tag at N-terminus, was expressed in E.coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 24-170aa
• Description: Neurotensin, also known as NTS, is a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea,10% glycerol
• Molecular Mass: 19.9 kDa (172aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMSDSEE EMKALEADFL TNMHTSKISK AHVPSWKMTL LNVCSLVNNL NSPAEETGEV HEEELVARRK LPTALDGFSL EAMLTIYQLH KICHSRAFQH WELIQEDILD TGNDKNGKEE VIKRKIPYIL KRQLYENKPR RPYILKRDSY YY
• Purity: >90% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml

Gene Information

• Gene Name: NTS neurotensin [ Homo sapiens ]
• Official Symbol: NTS
• Synonyms: NTS; neurotensin; neurotensin/neuromedin N; neuromedin N; NN; NT; NT/N; NTS1; NMN-125
• Gene ID: 4922
• mRNA Refseq: NM_006183
• Protein Refseq: NP_006174
• MIM: 162650
• UniProt ID: P30990
• Chromosome Location: 12q21
• Pathway: Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Peptide ligand-binding receptors, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by GPCR, organism-specific biosystem
• Function: neuropeptide hormone activity