Recombinant Human NTMT1 protein, His-tagged

• Cat.No.: NTMT1-201H
• Product Overview: Recombinant human NTMT1, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Description: NTMT1 also known as N-terminal Xaa-Pro-Lys N-methyltrasferase1 isoform a. NTMT1 is catalyzes the transfer of the methyl group from the S-adenosyl-l-methionine to the protein alpha-amine, resulting in formation of S-adenosyl-l-homocysteine and alpha-N-methylated proteins. NTMT1 is an interesting potential anticancer target because it is overexpressed in gastrointestinal cancers and plays an important role in cell mitosis.
• Source: E.coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 0.15M NaCl, 10% glycerol
• Molecular Mass: 28.1kDa (248aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSEFMTSEV IEDEKQFYSK AKTYWKQIPP TVDGMLGGYG HISSIDINSS RKFLQRFLRE GPNKTGTSCA LDCGAGIGRI TKRLLLPLFR EVDMVDITED FLVQAKTYLG EEGKRVRNYF CCGLQDFTPE PDSYDVIWIQ WVIGHLTDQH LAEFLRRCKG SLRPNGIIVI KDNMAQEGVI LDDVDSSVCR DLDVVRRIIC SAGLSLLAEE RQENLPDEIY HVYSFALR
• Purity: > 95% by SDS - PAGE
• Storage: Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5mg/ml (determined by Absorbance at 280nm)

Gene Information

• Gene Name: NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 [ Homo sapiens ]
• Official Symbol: NTMT1
• Synonyms: NRMT; NTM1A; AD-003; HOMT1A; C9orf32; METTL11A; N-terminal RCC1 methyltransferase; X-Pro-Lys N-terminal protein methyltransferase 1A; alpha N-terminal protein methyltransferase 1A; methyltransferase-like protein 11A
• mRNA Refseq: NM_001286796
• Protein Refseq: NP_001273725
• MIM: 613560
• UniProt ID: Q9BV86
• Chromosome Location: 9q34.11
• Function: N-terminal protein N-methyltransferase activity; protein methyltransferase activity