Recombinant Human NSD2 Protein, GST-tagged

• Cat.No.: NSD2-022H
• Product Overview: Recombinant Human NSD2 protein (941-1240) with a N-terminal GST-tag was expressed in E. coli.

Specification

• Description: This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences.
• Source: E. coli
• Species: Human
• Tag: GST
• Molecular Mass: 61.2 kDa
• Protein length: 941-1240
• Purity: ≥80% estimated by SDS-PAGE
• Stability: ≥ 1 year
• Storage: -80 centigrade

Gene Information

• Gene Name: NSD2 nuclear receptor binding SET domain protein 2 [ Homo sapiens (human) ]
• Official Symbol: NSD2
• Synonyms: NSD2; nuclear receptor binding SET domain protein 2; WHS; TRX5; KMT3F; KMT3G; MMSET; WHSC1; REIIBP; histone-lysine N-methyltransferase NSD2; IL5 promoter REII region-binding protein; Wolf-Hirschhorn syndrome candidate 1; multiple myeloma SET domain containing protein type III; nuclear SET domain-containing protein 2; probable histone-lysine N-methyltransferase NSD2; trithorax/ash1-related protein 5; EC 2.1.1.356
• Gene ID: 7468
• mRNA Refseq: NM_001042424
• Protein Refseq: NP_001035889
• MIM: 602952
• UniProt ID: O96028