Recombinant human NRG4, His-tagged

Cat.No. : NRG4-2472H
Product Overview : Recombinant human NRG4 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
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Species : Human
Source : E.coli
Tag : His
Description : NRG4 belongs to the neuregulin family and contains 1 EGF-like domain. The protein is low affinity ligand for the ERBB4 tyrosine kinase receptor. It concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. NRG4 does not bind to the ERBB1, ERBB2 and ERBB3 receptors.
Form : Liquid. In 20mM Tris-HCl(pH8.0) containing 30% glycerol, 0.15M NaCl, 1mM DTT
Molecular Mass : 9.1kDa (84aa) confirmed by MALDI-TOF
AA Sequence : MGSSHHHHHH SSGLVPRGSH MGSMPTDHEE PCGPSHKSFC LNGGLCYVIP TIPSPFCRCV ENYTGARCEE VFLPGSSIQT KSNL
Purity : >90% by SDS - PAGE
Applications : SDS-PAGE
Storage : Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration : 0.25 mg/ml (determined by Bradford assay)
Gene Name NRG4 neuregulin 4 [ Homo sapiens ]
Official Symbol NRG4
Synonyms NRG4; neuregulin 4; pro-neuregulin-4, membrane-bound isoform; HRG4; pro-NRG4; heregulin 4; DKFZp779N0541; DKFZp779N1944;
Gene ID 145957
mRNA Refseq NM_138573
Protein Refseq NP_612640
MIM 610894
UniProt ID Q8WWG1
Chromosome Location 15q23
Pathway ErbB receptor signaling network, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem; ErbB signaling pathway, conserved biosystem; ErbB4 signaling events, organism-specific biosystem; GRB2 events in ERBB2 signaling, organism-specific biosystem; Nuclear signaling by ERBB4, organism-specific biosystem;
Function growth factor activity;

Not For Human Consumption!

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