Recombinant human NRG4, His-tagged
Cat.No. : | NRG4-2472H |
Product Overview : | Recombinant human NRG4 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
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Species : | Human |
Source : | E.coli |
Tag : | His |
Description : | NRG4 belongs to the neuregulin family and contains 1 EGF-like domain. The protein is low affinity ligand for the ERBB4 tyrosine kinase receptor. It concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. NRG4 does not bind to the ERBB1, ERBB2 and ERBB3 receptors. |
Form : | Liquid. In 20mM Tris-HCl(pH8.0) containing 30% glycerol, 0.15M NaCl, 1mM DTT |
Molecular Mass : | 9.1kDa (84aa) confirmed by MALDI-TOF |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MGSMPTDHEE PCGPSHKSFC LNGGLCYVIP TIPSPFCRCV ENYTGARCEE VFLPGSSIQT KSNL |
Purity : | >90% by SDS - PAGE |
Applications : | SDS-PAGE |
Storage : | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.25 mg/ml (determined by Bradford assay) |
Gene Name | NRG4 neuregulin 4 [ Homo sapiens ] |
Official Symbol | NRG4 |
Synonyms | NRG4; neuregulin 4; pro-neuregulin-4, membrane-bound isoform; HRG4; pro-NRG4; heregulin 4; DKFZp779N0541; DKFZp779N1944; |
Gene ID | 145957 |
mRNA Refseq | NM_138573 |
Protein Refseq | NP_612640 |
MIM | 610894 |
UniProt ID | Q8WWG1 |
Chromosome Location | 15q23 |
Pathway | ErbB receptor signaling network, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem; ErbB signaling pathway, conserved biosystem; ErbB4 signaling events, organism-specific biosystem; GRB2 events in ERBB2 signaling, organism-specific biosystem; Nuclear signaling by ERBB4, organism-specific biosystem; |
Function | growth factor activity; |
◆ Recombinant Proteins | ||
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NRG4-825H | Recombinant Human NRG4 Protein, His-tagged | +Inquiry |
NRG4-6200M | Recombinant Mouse NRG4 Protein, His (Fc)-Avi-tagged | +Inquiry |
Nrg4-366M | Recombinant Mouse Nrg4 Protein, His-tagged | +Inquiry |
NRG4-333H | Recombinant Human NRG4 protein, His-tagged | +Inquiry |
◆ Cell & Tissue Lysates | ||
NRG4-1221HCL | Recombinant Human NRG4 cell lysate | +Inquiry |
Not For Human Consumption!
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