Recombinant Human NPC1 protein, His/FLAG-tagged

• Cat.No.: NPC1-1339H
• Product Overview: Recombinant Human NPC1(Arg372-Phe622) fused with His/FLAG tag at N-terminal was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: Flag&His
• Protein Length: Arg372-Phe622
• Predicted N Terminal: His
• Form: Lyophilized from sterile PBS, pH 7.4.1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.2. Please contact us for any concerns or special requirements.
• Molecular Mass: The recombinant human NPC1 consists 278 amino acids and predicts a molecular mass of 32 kDa.
• Endotoxin: < 1.0 EU per μg protein as determined by the LAL method.
• Purity: > 95 % as determined by SDS-PAGE
• Stability: Samples are stable for up to twelve months from date of receipt at -70 centigrade
• Storage: Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Publications:
  Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein (2018)

Gene Information

• Gene Name: NPC1 Niemann-Pick disease, type C1 [ Homo sapiens ]
• Official Symbol: NPC1
• Synonyms: NPC1; Niemann-Pick disease, type C1; Niemann-Pick C1 protein; NPC; FLJ98532
• Gene ID: 4864
• mRNA Refseq: NM_000271
• Protein Refseq: NP_000262
• MIM: 607623
• UniProt ID: O15118
• Chromosome Location: 18q11-q12
• Pathway: Lysosome, organism-specific biosystem; Lysosome, conserved biosystem
• Function: hedgehog receptor activity; protein binding; receptor activity; sterol transporter activity; transmembrane signaling receptor activity