Recombinant Human Notch Homolog 3 (Drosophila), Fc Chimera

• Cat.No.: NOTCH3-2543H
• Product Overview: Ecombinant Human Notch Homolog 3 produced inSf21 cellswas fused to Fc region of human.

Specification

• Species: Human
• Source: Sf21 Cells
• Tag: Fc
• Description: This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
• Molecular Weight: Calculated mol wt 71.4 kDa; mol wt 85-95 kDa by SDS-PAGE (reducing).
• Purity: ≥90% (SDS-PAGE).
• Form: Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
• Analysis Note: The biological activity is measured by its ability to bind Jagged-1.
• Storage: −20°C.

Gene Information

• Gene Name: NOTCH3 Notch homolog 3 (Drosophila) [ Homo sapiens ]
• Synonyms: NOTCH3; Notch homolog 3 (Drosophila); CASIL; CADASIL; neurogenic locus notch homolog protein 3; notch 3;Notch (Drosophila) homolog 3; Notch 3 extracellular truncation; Notch 3 intracellular domain; Notch homolog 3
• Gene ID: 4854
• mRNA Refseq: NM_000435
• Protein Refseq: NP_000426
• MIM: 600276
• UniProt ID: Q9UM47
• Chromosome Location: 19p13.2-p13.1
• Pathway: Dorso-ventral axis formation; Notch signaling pathway
• Function: calcium ion binding; protein binding; receptor activity