Recombinant Human NK2 homeobox 2 Protein, His&Flag&StrepII tagged

• Cat.No.: NKX2-2-153H
• Product Overview: Recombinant human NKX2-2 protein (O95096) (Asp 20-Lys 128) with a Twin strep tag at the N-terminus and both His, Flag tag at the C-terminus was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: Flag&His&Twin Strep
• Protein Length: 20-128aa
• Description: The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas. May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter.
• Tag: N-Twin strep and C-His&Flag
• Molecular Mass: 17.9 kDa
• Endotoxin: Less than 1.0 EU/μg by the LAL method.
• Purity: >90% as determined by SDS-PAGE.
• Storage: Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
• Reconstitution: Reconstitute at 250 μg/mL in sterile water.

Gene Information

• Gene Name: NKX2-2 NK2 homeobox 2 [ Homo sapiens (human) ]
• Official Symbol: NKX2-2
• Synonyms: NKX2-2; NK2 homeobox 2; NK 2 (Drosophila) homolog B, NK2 transcription factor related, locus 2 (Drosophila), NKX2B; homeobox protein Nkx-2.2; NKX2.2; NK-2 homolog B; homeobox protein NK-2 homolog B; NK2 transcription factor-like protein B; NK2 transcription factor related, locus 2; NKX2B
• Gene ID: 4821
• mRNA Refseq: NM_002509
• Protein Refseq: NP_002500
• MIM: 604612
• UniProt ID: O95096