Recombinant Human NFKB2, GST-tagged

• Cat.No.: NFKB2-4859H
• Product Overview: Recombinant human NFKB2 (1-454) was expressed in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: 1-454
• Description: This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants.?
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Molecular Mass: ~84 kDa
• Purity: >75%
• Applications: Western Blot
• Stability: 1 yr at -70oC from date of shipment.
• Storage: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.2 ug/ul

Gene Information

• Gene Name: NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) [ Homo sapiens ]
• Official Symbol: NFKB2
• Synonyms: NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100); nuclear factor NF-kappa-B p100 subunit; LYT 10; NF kB2; p52; p105; oncogene Lyt-10; DNA-binding factor KBF2; lymphocyte translocation chromosome 10 protein; nuclear factor of kappa light chain gene enhancer in B-cells 2; H2TF1; LYT10; LYT-10; NF-kB2
• Gene ID: 4791
• mRNA Refseq: NM_002502
• Protein Refseq: NP_002493
• MIM: 164012
• UniProt ID: Q00653
• Chromosome Location: 10q24
• Pathway: Cytokine Signaling in Immune system; DEx/H-box helicases activate type I IFN and inflammatory cytokines production; Epstein-Barr virus infection
• Function: DNA binding; protein binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity