NFKB2
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Official Full Name
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) -
Overview
This gene encodes one of the NF-kappaB family of transcription factors which are characterized by a Rel homology domain (RHD) in the N-terminal region. These transcription factors have key roles in regulating immunity, stress responses, apoptosis, and differentiation. The p100 form of this gene is processed in the proteasome to the p52 form. NF-kappaB molecules containing p52 participate in noncanonical NF-kappaB regulatory pathways. Recent reviews of the NF-kappaB signalling pathways include PubMed 17072323, 18267068, 18515173, and 21772278. -
Synonyms
NFKB2;nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100);nuclear factor NF-kappa-B p100 subunit;LYT 10;NF kB2;p52;p105;oncogene Lyt-10;DNA-binding factor KBF2;lymphocyte translocation chromosome 10 protein;nuclear fa
Recombinant Proteins
- Human
- Chicken
- Mouse
- Zebrafish
- Sf9 Insect Cell
- E.coli
- Mammalian Cell
- Insect Cell
- HEK293
- HEK293T
- Mammalian cells
- GST
- His
- His&T7
- His&MBP
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
NFKB2 involved in several pathways and played different roles in them. We selected most pathways NFKB2 participated on our site, such as MAPK signaling pathway,NF-kappa B signaling pathway,Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFKB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pathways in cancer | FGF7,TRAF6,GNG5,AXIN2,MITF,GNB3,SMAD2,PAX8,LAMA4,FZD1 |
| MAPK signaling pathway | CACNA1C,NGF,MAPT,STK4,CACNG6A,NTRK1,PLA2G4A,RAP1A,HSPA1L,TNFRSF1A |
| Epstein-Barr virus infection | PSMD11,GSK3B,PSMD2,HLA-C,VIM,CD38,TYK2,DDX58,PSMC3,Fcer2a |
| Viral carcinogenesis | HIST2H2BE,SYK,TBP,MAPKAPK2,TRAF5,HIST1H4N,H2-Q10,LYN,HDAC10,KAT2B |
| HTLV-I infection | WNT5B,CANX,LTA,TBPL2,CD3E,BUB3,IL2RB,CDC20,ANAPC1,DVL1 |
| NF-kappa B signaling pathway | TNFRSF13C,IRAK4,PLCG2,TNFSF13B,TNFAIP3,TRAF1,IL1R1,LTB,PLCG1,CFLAR |
| Legionellosis | NAIP6,Casp3,HSPA1B,CXCL2,CASP7,IL12B,IL12A,HSPD1,HSPA1L,HSPA6 |
| Osteoclast differentiation | MAP3K14,PIK3CB,MAPK10,TGFBR2,PLCG2,PIK3R2,PPP3CA,MAPK12,FOS,FCGR1 |
Protein Function
NFKB2 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,chromatin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFKB2 itself. We selected most functions NFKB2 had, and list some proteins which have the same functions with NFKB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | ISL1,GATA6,HDAC5,SP110,EGR2,UBTFL,JUB,SMARCA2,TRIM37,TMPOA |
| transcription coactivator activity | MED21,MED7,PML,ENY2,THRAP3,CDK7,Ankar,ESRRB,HCFC1,LPIN1 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | SIX2,CREB3,BSX,TFE3B,MZF1,PDX1,TCF4,EBF1,MITFA,ELF3 |
| transcription factor activity, sequence-specific DNA binding | ZIM3,HOXD10,ZKSCAN4,ATF3,HOXC4A,NEUROD1,NFE2L2B,CHES1,ZNF550,RUNX2B |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | CAMTA1,NRF1,ARNT2,FLI1,FOXC2,MTF1,HNRNPK,IRF1,DDIT3,HLTF |
| protein binding | FAM115A,TRIM37,CHCHD3,RPS6KA5,MAP1LC3B,CST3,AIMP2,SSB,TFB1M,ATG13 |
Interacting Protein
NFKB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFKB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFKB2.
NFKB1;MAP3K8;RELB;REL;EPS8
NFKB2 Related Signal Pathway
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References
- Lee, CE; Fulcher, DA; et al. Autosomal-dominant B-cell deficiency with alopecia due to a mutation in NFKB2 that results in nonprocessable p100. BLOOD 124:2964-2972(2014).
- Chen, K; Coonrod, EM; et al. Germline Mutations in NFKB2 Implicate the Noncanonical NF-kappa B Pathway in the Pathogenesis of Common Variable Immunodeficiency. AMERICAN JOURNAL OF HUMAN GENETICS 93:812-824(2013).
