Recombinant Human NFKB Inhibitor Interacting Ras-Like 2, His-tagged

• Cat.No.: NKIRAS2-5596H
• Product Overview: Recombinanthuman NKIRAS2 protein, fused to His-tag at N-terminus, was expressed inE.coli and purified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: NKIRAS2,also known as KBRAS2, is similar to the Ras-like small GTPases that associatewith IkappaB. These Ras-like proteins, NKIRAS1 and NKIRAS2, interact with thePEST domains of IκBα and IκBβ and decrease their rate of degradation. NKIRAS2shows 71% identity to KBRAS1. NKIRAS2 is an inhibitor of the transcriptionfactor NF-kappaB.
• Form: Liquid.In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol, 0.1M NaCl.
• Molecular Weight: 24.0 kDa(215aa), confirmed by MALDI-TOF.
• Purity: > 90%by SDS – PAGE.
• Concentration: 1 mg/ml(determined by Bradford assay).
• Sequences of aminoacids: MGSSHHHHHHSSGLVPRGSH MGSHMGKSCK VVVCGQASVG KTSILEQLLY GNHVVGSEMI ETQEDIYVGS IETDRGVREQVRFYDTRGLR DGAELPRHCF SCTDGYVLVY STDSRESFQR VELLKKEIDK SKDKKEVTIV VLGNKCDLQEQRRVDPDVAQ HWAKSEKVKL WEVSVADRRS LLEPFVYLAS KMTQPQSKSA FPLSRKNKGS GSLDG
• Storage: Can bestored at +4°C short term (1-2 weeks). For long term storage, aliquot andstore at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• OfficialSymbol: NKIRAS2

Gene Information

• Gene Name: NKIRAS2 NFKB inhibitorinteracting Ras-like 2 [ Homo sapiens ]
• Synonyms: NKIRAS2; NFKBinhibitor interacting Ras-like 2; KBRAS2; kappaB-Ras2; NF-kappa-Binhibitor-interacting Ras-like protein 2; kappa B-Ras protein 2; I-kappa-B-interactingRas-like protein 2; NFKB inhibitor interacting Ras-like protein 2
• Gene ID: 28511
• mRNA Refseq: NM_001144927
• Protein Refseq: NP_001138399
• MIM: 604497
• UniProt ID: Q9NYR9
• Chromosome Location: 17q21.2
• Function: GTP binding; GTPaseactivity; nucleotide binding