Recombinant Human NF2 Protein, His-tagged

• Cat.No.: NF2-747H
• Product Overview: Recombinant Human NF2, transcript variant 13, fused with His tag at N-terminal was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.
• Form: 50mM Tris, 8M Urea, pH8.0.
• Molecular Mass: 58.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: NF2 neurofibromin 2 (merlin) [ Homo sapiens ]
• Official Symbol: NF2
• Synonyms: NF2; neurofibromin 2 (merlin); neurofibromin 2 (bilateral acoustic neuroma); merlin; moesin ezrin radixin like; schwannomin; schwannomerlin; neurofibromin-2; moesin-ezrin-radixin like; moesin-ezrin-radixin-like protein; moesin-ezrin-radizin-like protein; ACN; SCH; BANF
• Gene ID: 4771
• mRNA Refseq: NM_000268
• Protein Refseq: NP_000259
• MIM: 607379
• UniProt ID: P35240