NF2
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Official Full Name
neurofibromin 2 (merlin) -
Overview
This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts. -
Synonyms
NF2;neurofibromin 2 (merlin);merlin;neurofibromin 2 (bilateral acoustic neuroma);Moesin-ezrin-radixin-like protein;SCH;CAN;BANF;OTTHUMP00000199607;moesin-ezrin-radixin like;moesin-ezrin-radizin-like protein;neurofibromin-2;schwannomerlin;schwannomin;ACN;OTTHUMP00000028855;OTTHUMP00000199606;OTTHUMP00000199608;OTTHUMP00000199609;OTTHUMP00000199610;OTTHUMP00000199611;OTTHUMP00000199621;OTTHUMP00000199622
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- His
- His&T7
- GST
- Non
- Avi&Fc&His
- His&Trx
Involved Pathway
NF2 involved in several pathways and played different roles in them. We selected most pathways NF2 participated on our site, such as Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hippo signaling pathway | WNT5B,PPP2R2D,FZD10,LLGL2,LEF1,WNT7A,NKD1,ACTG1,TGFBR1,WWC1 |
Protein Function
NF2 has several biochemical functions, for example, actin binding,beta-catenin binding,integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NF2 itself. We selected most functions NF2 had, and list some proteins which have the same functions with NF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| integrin binding | FAP,VCAM1,DMP1,SYK,WISP3,ITGB1BP2,CALR,TNN,PXN,ESM1 |
| protein binding | ZBTB17,SHOC2,NAA30,HLTF,CHP,CLCNKB,PYGO2,AKAP1,HOXA10,LARP4 |
| protein domain specific binding | LIN7C,PPARA,DBNL,WNT5A,ETV6,CBX3,TNFAIP1,HSPA5,VRK2,ODF1 |
| actin binding | DIAPH1,DAAM1B,XIRP1,SPIRE1A,FER,ACTR2B,PARVB,PTK2,WASLA,C19orf21 |
| beta-catenin binding | SLC9A3R1,CDH1,TAX1BP3,CHD8,TCF7L1B,BCL9L,BTRC,ESR1,CD2AP,CDH24 |
Interacting Protein
NF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NF2.
AMOT;MAP3K11;GTPBP4
NF2 Related Signal Pathway
Resources
Research Area
Tumor SuppressorsMultiple Sclerosis and Myelin Related Molecules
Focal Adhesion Adaptor and Scaffold Proteins
Liver Cancer Stem Cell Markers
Related Services
Related Products
References
- Bhimrao, SK; Maguire, J; et al. Lack of Association between Human Herpesvirus and Vestibular Schwannoma: Analysis of 121 Cases. OTOLARYNGOLOGY-HEAD AND NECK SURGERY 152:513-517(2015).
- Shapiro, IM; Kolev, VN; et al. Merlin Deficiency Predicts FAK Inhibitor Sensitivity: A Synthetic Lethal Relationship. SCIENCE TRANSLATIONAL MEDICINE 6:-(2014).
