Recombinant Human neurogenin 3, His-tagged

• Cat.No.: NEUROG3-401H
• Product Overview: NEUROG3, 1-214aa, Human, His tag, E.coli

Specification

• Description: NEUROG3 is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4). Recombinant human NeuroG3 protein, fused to His-tag at N-terminus, was expressed in E.coli
• Source: E.coli
• Species: Human
• Tag: His-tag
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M Urea
• Molecular Mass: 25.1 kDa (234aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MTPQPSGAPT VQVTRETERS FPRASEDEVT CPTSAPPSPT RTRGNCAEAE EGGCRGAPRK LRARRGGRSR PKSELALSKQ RRSRRKKAND RERNRMHNLN SALDALRGVL PTFPDDAKLT KIETLRFAHN YIWALTQTLR IADHSLYALE PPAPHCGELG SPGGSPGDWG SLYSPVSQAG SLSPAASLEE RPGLLGATSS ACLSPGSLAF SDFL
• Purity: >85% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.25 mg/ml (determined by Bradford assay)
• Protein length: 1-214 a.a.

Gene Information

• Gene Name: NEUROG3 neurogenin 3 [ Homo sapiens ]
• Official Symbol: NEUROG3
• Synonyms: NEUROG3; neurogenin 3; neurogenin-3; Atoh5; bHLHa7; Math4B; ngn3; protein atonal homolog 5; class A basic helix-loop-helix protein 7; NGN-3
• Gene ID: 50674
• mRNA Refseq: NM_020999
• Protein Refseq: NP_066279
• MIM: 604882
• UniProt ID: Q9Y4Z2
• Chromosome Location: 10q21.3
• Pathway: Developmental Biology, organism-specific biosystem; Maturity onset diabetes of the young, organism-specific biosystem; Maturity onset diabetes of the young, conserved biosystem; Notch-mediated HES/HEY network, organism-specific biosystem; Regulation of beta-cell development, organism-specific biosystem; Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells, organism-specific biosystem; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells, organism-specific biosystem
• Function: DNA binding; double-stranded DNA binding; transcription coactivator activity