Recombinant Human Neuroblastoma RAS Viral (v-ras) Oncogene Homolog

• Cat.No.: NRAS-1279H
• Product Overview: Recombinanthuman NRAS is Expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: NRAS proteins aremembers of the superfamily of small GTPbinding proteins that function asmolecular switches controlling a variety of signalling and transportpathways. NRAS is one of the classic humanRas proteins (H-, N-, K-Ras4A, and K-Ras4B). NRASdeltaC comprises the first 167 residues of Ras that are sufficient forbinding guanine nucleotides and hydrolysis of GTP, but lacks the C-terminalCaaX motif necessary for membrane localization of Ras. Protein preparation is100% GDP-loaded, measured by HPLC.
• Form: Liquid solution in64 mM Tris-HCl Buffer, pH 7.2, + 10 Mm MgCl2 + 5 mM DTE.
• Purity: > 95%as determined by SDS-PAGE analysis
• Applications: In vitro transcriptionassays; DNA-protein interaction assays; Protein-protein interaction assays.
• storage: Store at-80°C. Stablefor 1 year. For long term storage, aliquot and freeze at -80°C. Avoidrepeated freeze-thaw cycles.
• OfficialSymbol: NRAS
• Pathways: Acute myeloid leukemia; Axonguidance; B cell receptor signaling pathway; Bladder cancer; Chemokinesignaling pathway; Chronic myeloid leukemia; Endometrial cancer; ErbBsignaling pathway; Fc epsilon RI signaling pathway; Gap junction; Glioma;GnRH signaling pathway; Insulin signaling pathway; Long-term depression;Long-term potentiation; MAPK signaling pathway; Melanogenesis; Melanoma;Natural killer cell mediated cytotoxicity; Neurotrophin signaling pathway;Non-small cell lung cancer; Pathways in cancer; Prostate cancer; Regulationof actin cytoskeleton; Renal cell carcinoma; T cell receptor signalingpathway; Thyroid cancer; Tight junction; VEGF signaling pathway

Gene Information

• Gene Name: NRAS neuroblastoma RAS viral(v-ras) oncogene homolog [ Homo sapiens ]
• Synonyms: NRAS; neuroblastoma RAS viral(v-ras) oncogene homolog; NS6; ALPS4; N-ras; NRAS1; GTPase NRas; N-rasprotein part 4; transforming protein N-Ras; v-ras neuroblastoma RAS viraloncogene homolog; N-ras; Transforming protein N-Ras
• Gene ID: 4893
• mRNA Refseq: NM_002524
• Protein Refseq: NP_002515
• MIM: 164790
• UniProt ID: P01111
• Chromosome Location: 1p13.2
• Function: GTP binding; GTPase activity;nucleotide binding; protein binding