Recombinant Human NEURL2, His-tagged

• Cat.No.: NEURL2-2297H
• Product Overview: Recombinant human NEURL2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Description: NEURL2 plays an important role in the process of myofiber differentiation and maturation. This protein is probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. It probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, NEURL2 controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M UREA, 10% glycerol
• Molecular Mass: 34.1kDa
• Protein length: 308aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMAAASEP VDSGALWGLE RPEPPPTRFH RVHGANIRVD PSGTRATRVE SFAHGVCFSR EPLAPGQVFLVEIEEKELGW CGHLRLGLTA LDPASLAPVP EFSLPDLVNL GHTWVFAITR HHNRVPREGR PEAEAAAPSR PPTLLVEPYL RIEQFRIPRDRLVGRSRPGL YSHLLDQLYE LNVLPPTARR SRLGVLFCPR PDGTADMHII INGEDMGPSA RGLPAAQPLY AVVDVFASTK SVRLVQLEYGLPSLQTLCRL VIQRSMVHRL AIDGLHLPKE LKDFCKYE
• Purity: >85% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/ml

Gene Information

• Gene Name: NEURL2 neuralized homolog 2 (Drosophila) [ Homo sapiens ]
• Official Symbol: NEURL2
• Synonyms: NEURL2; neuralized homolog 2 (Drosophila); C20orf163, chromosome 20 open reading frame 163 , neuralized like 2 (Drosophila); neuralized-like protein 2; dJ337O18.6; FLJ30259; Ozz; Ozz E3; neuralized-like 2; OZZ; Ozz-E3; C20orf163; MGC125934; MGC125935
• Gene ID: 140825
• mRNA Refseq: NM_080749
• Protein Refseq: NP_542787
• MIM: 608597
• UniProt ID: Q9BR09
• Chromosome Location: 20q13.12