Recombinant Human Neuregulin 4, His-tagged

• Cat.No.: NRG4-18H
• Product Overview: Recombinant Human neuregulin 4 encoding the human sNRG4 was recombined with Hexa-histidine tag at the N-Terminus. That was expressed inE.Coli, and purified by Ni-NTA column. MW=6.7 KD.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: sNRG4 is a low affinity ligand for the ERBB4 tyrosine kinase receptor. It concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors sNRG4 does not bind to the ERBB1, ERBB2 and ERBB3 receptors.
• Purity: >95% in SDSgel.
• Formulation: Lyophilized 100 μg human NRG4 in 50 μl of TBS ( 20 mM Tris, 50mM NaCl, pH8.0 ). Carry free.
• Reconstitution: Add 500μl deionized water or TBS to the vial to prepare a working stock solution at 200 μg/mL. Allow to set at least 30 minutes at 4℃, mix well.
• Application: Cell biology, ELISA.
• Storage: Store lyophilized protein at -20℃ to-70℃. Lyophilized protein is stable for up to 6 months from date of receipt at - 20℃ to -70℃. Upon reconstitution, this protein can be stored at -20℃ for up to a few weeks or at -70℃ in a manual defrost freezer for long term storage (six months). Aliquot reconstituted protein to avoid repeated freeze / thaw cycles.

Gene Information

• Gene Name: NRG4 neuregulin 4 [ Homo sapiens ]
• Synonyms: NRG4;neuregulin 4; HRG4; DKFZp779N0541; DKFZp779N1944; Pro-neuregulin-4, membrane-bound isoform; Pro-NRG4; Neuregulin-4; NRG-4; OTTHUMP00000183575; heregulin 4
• Gene ID: 145957
• mRNA Refseq: NM_138573
• Protein Refseq: NP_612640
• MIM: 610894
• UniProt ID: Q8WWG1
• Chromosome Location: 15q23
• Pathway: ErbB signaling pathway
• Function: growth factor activity