Recombinant Human NDE1, His-tagged

• Cat.No.: NDE1-28795TH
• Product Overview: Recombinant full length Human NDE1, isoform 2 (amino acids 1-335) with N terminal His tag; 355 amino acids, 39.9 kDa.

Specification

• Description: This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Alternative splicing results in multiple transcript variants.
• Protein length: 335 amino acids
• Conjugation: HIS
• Molecular Weight: 39.900kDa inclusive of tags
• Source: E. coli
• Form: Liquid
• Purity: by SDS-PAGE
• Storage buffer: pH: 8.00Constituents:0.32% Tris HCl, 20% Glycerol, 0.08% DTT, 1.17% Sodium chloride
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMEDSGKTFSSEEEEANYWKD LAMTYKQRAENTQEELREFQEGSREYEAELETQLQQIETR NRDLLSENNRLRMELETIKEKFEVQHSEGYRQISALEDDL AQTKAIKDQLQKYIRELEQANDDLERAKRATIMSLEDFEQ RLNQAIERNAFLESELDEKENLLESVQRLKDEARDLRQEL AVQQKQEKPRTPMPSSVEAERTDTAVQATGSVPSTPIAHR GPSSSLNTPGSFRRGLDDSTGGTPLTPAARISALNIVGDL LRKVGALESKLASCRNLVYDQSPNRTGGPASGRSSKNRDG GERRPSSTSVPLGDKGLDTSCRWLSKSTTRSSSSC
• Sequence Similarities: Belongs to the nudE family.

Gene Information

• Gene Name: NDE1 nudE nuclear distribution gene E homolog 1 (A. nidulans) [ Homo sapiens ]
• Official Symbol: NDE1
• Synonyms: NDE1; nudE nuclear distribution gene E homolog 1 (A. nidulans); nuclear distribution protein nudE homolog 1; FLJ20101; NUDE
• Gene ID: 54820
• mRNA Refseq: NM_001143979
• Protein Refseq: NP_001137451
• MIM: 609449
• Uniprot ID: Q9NXR1
• Chromosome Location: 16p13.11
• Pathway: Cell Cycle, Mitotic, organism-specific biosystem; Centrosome maturation, organism-specific biosystem; DNA Replication, organism-specific biosystem; G2/M Transition, organism-specific biosystem; Loss of Nlp from mitotic centrosomes, organism-specific biosystem
• Function: microtubule binding; protein binding