Recombinant Human NCOA2 Protein, N-His-tagged

• Cat.No.: NCOA2-23H
• Product Overview: Purified recombinant protein of Human nuclear receptor coactivator 2 (NCOA2),Met1-Ile280, with N-terminal His tag, expressed in E. coli.

Specification

• Description: The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants.
• Source: E. coli
• Species: Human
• Tag: His
• Protein length: Met1-Ile280
• Form: 25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 10% glycerol.
• Molecular Mass: 31.8 kDa
• AA Sequence: A DNA sequence encoding the region(Met1-Ile280)of NCOA2
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Notes: For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
• Storage: Store at -80 centigrade.
• Concentration: >0.05 μg/μL as determined by microplate BCA method.
• Use/Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: NCOA2 nuclear receptor coactivator 2 [ Homo sapiens (human) ]
• Official Symbol: NCOA2
• Synonyms: NCOA2; nuclear receptor coactivator 2; bHLHe75; GRIP1; KAT13C; NCoA-2; SRC2; TIF2
• Gene ID: 10499
• mRNA Refseq: NM_006540.4
• Protein Refseq: NP_006531.1
• MIM: 601993
• UniProt ID: Q15596