Recombinant Human NCOA1, His-tagged

• Cat.No.: NCOA1-29750TH
• Product Overview: Recombinant fragment, corresponding to amino acids 627-786 of human KAT13A / SRC1, cloned into an expression vector that contains a specific 15 residue consensus biotinylation peptide and the coding sequence of the biotin ligase.

Specification

• Description: The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Widely expressed.
• Form: Liquid
• Purity: Immunogen affinity purified
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 20mM Tris HCl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the SRC/p160 nuclear receptor coactivator family.Contains 1 basic helix-loop-helix (bHLH) domain.Contains 1 PAS (PER-ARNT-SIM) domain.
• Protein length: 627-786 a.a.

Gene Information

• Gene Name: NCOA1 nuclear receptor coactivator 1 [ Homo sapiens ]
• Official Symbol: NCOA1
• Synonyms: NCOA1; nuclear receptor coactivator 1; bHLHe74; F SRC 1; KAT13A; NCoA 1; RIP160; SRC1
• Gene ID: 8648
• mRNA Refseq: NM_003743
• Protein Refseq: NP_003734
• MIM: 602691
• Uniprot ID: Q15788
• Chromosome Location: 2p23
• Pathway: Adipogenesis, organism-specific biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Energy Metabolism, organism-specific biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem