Recombinant Human NCL, His-tagged

• Cat.No.: NCL-27593TH
• Product Overview: Recombinant fragment, corresponding to amino acids 323-710 of Human Nucleolin with an N terminal His tag. Predicted MWt:43 kDa

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 323-710 a.a.
• Description: Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20.
• Form: Lyophilised. 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5.
• AA Sequence: LKTGISDVFAKNDLAVVDVRIGMTRKFGYVDFESAEDLEKALELTGLKVFGNEIKLEKPKGKDSKKERDA RTLLAKNLPYKVTQDELKEVFEDAAEIRLVSKDGKSKGIAYIEFKTEADAEKTFEEKQGTEI DGRSISLYYTGEKGQNQDYRGGKN STW SGESKTLVLSNLSYSATEETLQEVFEKATFIKV PQ NQNGKSKGYAFIEFASFE DAKEALNSCNKREIEGRAIR LELQGPRGSPNARSQPSKT LFVKGLSEDTTEET LKESFDGSVRARIVTDRETGSSKGFGFVDFNSEEDAKAAKEAMED G EIDGNKV TLDWAKPKGEGGFGGRGGGRGGFGGRGGGR GGRGGFGGRGRGGFGGRGGFRGG RGGGGDHKPQGKKTK FE
• Applications: SDS-PAGE
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
• Reconstitution: Reconstitute with 105 µl aqua dest.

Gene Information

• Gene Name: NCL nucleolin [ Homo sapiens (human) ]
• Official Symbol: NCL
• Synonyms: NCL; C23; nucleolin
• Gene ID: 4691
• mRNA Refseq: NM_005381
• Protein Refseq: NP_005372
• MIM: 164035
• UniProt ID: P19338
• Chromosome Location: 2q37.1
• Pathway: Aurora B signaling; Pathogenic Escherichia coli infection; Regulation of Telomerase
• Function: RNA binding; identical protein binding; protein C-terminus binding