NCL
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Official Full Name
nucleolin -
Overview
Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. [provided by RefSeq, Jul 2008] -
Synonyms
NCL;nucleolin;C23
Recombinant Proteins
- Mouse
- Human
- Zebrafish
- Chicken
- Cynomolgus
- E.coli
- Yeast
- Insect Cells
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- His
- GST
- Myc&DDK
- Non
- Flag
- mFc
- Fc
- His&Fc&Avi
- His&GST
- His&SUMO
Involved Pathway
NCL involved in several pathways and played different roles in them. We selected most pathways NCL participated on our site, such as Pathogenic Escherichia coli infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pathogenic Escherichia coli infection | TUBA1A,KRT18,PRKCA,ARHGEF2,TUBA4A,ACTG1,CLDN1,TUBB2A,CDH1,TUBA3C |
Protein Function
NCL has several biochemical functions, for example, ErbB-4 class receptor binding,RNA binding,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NCL itself. We selected most functions NCL had, and list some proteins which have the same functions with NCL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| single-stranded DNA binding | TREX1,RAD51L3,HNRNPA1,RBMS1,POLR2GL,PCBP1,BLM,TDP1,HMGB2,CNBP |
| protein binding | EGLN3,GTF2A1L,ATP1A1,CATSPER1,SOX30,GPANK1,ZBTB7C,DOK6,Chrng,EIF4H |
| calcium ion binding | CAPN8,PCDHGA10,MMP10,CETN2,EFCAB4B,CABP1,C1RA,CHP,ELTD1,CAPNS1A |
| laminin binding | ADAM9,LYPD5,GPC1,NID1,ITGA9,ITGA3,ITGB1,TINAGL1,LGALS1,BCAM |
| histone binding | USP16,ASF1B,HIST1H4B,RBBP4,UIMC1,CHD2,H3F3A,PIH1D1,HINFP,HIST1H4M |
| poly(A) RNA binding | CNOT1,EIF4ENIF1,MTPAP,GLRX3,HIST1H47,EIF3H,HNRNPA2B1,TRMT2A,SECISBP2,NKRF |
| rRNA primary transcript binding | IMP4,RPF1,PTRF |
| selenocysteine insertion sequence binding | SECISBP2 |
| identical protein binding | FZD1,IL12B,ORAI1,PICK1,S100A1,TRP53,ERBB2,TP63,C,IRF3 |
Interacting Protein
NCL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCL here. Most of them are supplied by our site. Hope this information will be useful for your research of NCL.
COL18A1;MDM2
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References
- Santacatterina, F; Chamorro, M; et al. Quantitative analysis of proteins of metabolism by reverse phase protein microarrays identifies potential biomarkers of rare neuromuscular diseases. JOURNAL OF TRANSLATIONAL MEDICINE 13:-(2015).
- Han, SQ; Meng, YC; et al. The ErbB2-targeting antibody trastuzumab and the small-molecule SRC inhibitor saracatinib synergistically inhibit ErbB2-overexpressing gastric cancer. MABS 6:403-408(2014).
