Recombinant Human NCK1, His-tagged

Description :	The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found.
Protein length :	377 amino acids
Conjugation :	HIS
Molecular Weight :	45.000kDa inclusive of tags
Source :	E. coli
Form :	Liquid
Purity :	>90% by SDS-PAGE
Storage buffer :	Preservative: NoneConstituents: 20% Glycerol, 50mM Sodium chloride, 20mM Tris HCl, 1mM EDTA, 1mM DTT, pH 8.0
Storage :	Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids :	MGSSHHHHHH SSGLVPRGSH MAEEVVVVAK FDYVAQQEQE LDIKKNERLW LLDDSKSWWR VRNSMNKTGF VPSNYVERKN SARKASIVKN LKDTLGIGKV KRKPSVPDSA SPADDSFVDP GERLYDLNMP AYVKFNYMAE REDELSLIKG TKVIVMEKCS DGWWRGSYNG QVGWFPSNYV TEEGDSPLGD HVGSLSEKLA AVVNNLNTGQ VLHVVQALYP FSSSNDEELN FEKGDVMDVI EKPENDPEWW KCRKINGMVG LVPKNYVTVM QNNPLTSGLE PSPPQCDYIR PSLTGKFAGN PWYYGKVTRH QAEMALNERG HEGDFLIRDS ESSPNDFSVS LKAQGKNKHF KVQLKETVYCIGQRKFSTME ELVEHYKKAP IFTSEQGEKL YLVKHLS
Sequence Similarities :	Contains 1 SH2 domain.Contains 3 SH3 domains.

Gene Name	NCK1 NCK adaptor protein 1 [ Homo sapiens ]
Official Symbol	NCK1
Synonyms	NCK1; NCK adaptor protein 1; NCK; cytoplasmic protein NCK1; NCKalpha;
Gene ID	4690
mRNA Refseq	NM_001190796
Protein Refseq	NP_001177725
MIM	600508
Uniprot ID	P16333
Chromosome Location	3q21
Pathway	Activation of Rac, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Arf6 signaling events, organism-specific biosystem; Axon guidance, organism-specific biosystem;
Function	cytoskeletal adaptor activity; protein binding; protein domain specific binding; receptor binding; receptor signaling complex scaffold activity;

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