Recombinant Human NBL1, His-tagged

• Cat.No.: NBL1-7523H
• Product Overview: Recombinant human NBL1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 18-181aa
• Antigen Description: Neuroblastoma suppressor of tumorigenicity 1, also known as NBL1, is a member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. NBL1 is a candidate as a tumor suppressor of neuroblastoma and may play a role in preventing cells from entering the final stage (G1/S) of the transformation process. It is produced in small neurons of the dorsal root ganglion and its expression is activated by MATH-1.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol, 1mM DTT
• Molecular Mass: 20 kDa (187aa) confirmed by -
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSAPPPINK LALFPDKSAW CEAKNITQIV GHSGCEAKSI QNRACLGQCF SYSVPNTFPQ STESLVHCDS CMPAQSMWEI VTLECPGHEE VPRVDKLVEK ILHCSCQACG KEPSHEGLSV YVQGEDGPGS QPGTHPHPHP HPHPGGQTPE PEDPPGAPHT EEEGAED
• Purity: >90% as determined by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C.Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml

Gene Information

• Gene Name: NBL1 neuroblastoma, suppression of tumorigenicity 1 [ Homo sapiens ]
• Official Symbol: NBL1
• Synonyms: NBL1; neuroblastoma, suppression of tumorigenicity 1; neuroblastoma suppressor of tumorigenicity 1; D1S1733E; DAN; DAND1; differential screening selected gene aberrant in neuroblastoma; NB; neuroblastoma candidate region; suppression of tumorigenicity 1; NO3; DAN domain family member 1; differential screening-selected gene aberrant in neuroblastoma; neuroblastoma candidate region, suppression of tumorigenicity 1; MGC8972
• Gene ID: 4681
• mRNA Refseq: NM_001204084
• Protein Refseq: NP_001191013
• MIM: 600613
• UniProt ID: P41271
• Chromosome Location: 1p36.3-p36.2