Recombinant Human NARS Protein (Met1-Arg330), His tagged

• Cat.No.: NARS-4660H
• Product Overview: Recombinant human NARS (Met1-Arg330) fused with His tag was expressed in E. coli.

Specification

• Description: Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing. Has an ATP-independent activity. Specifically cleaves peptides in the range of 5 to 65 residues. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Degrades the transit peptides of mitochondrial proteins after their cleavage. Also degrades other unstructured peptides. It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion. It is a highly efficient protease, at least toward amyloid-beta protein 40. Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 38.33 kDa
• Protein length: Met1-Arg330
• Purity: >90% as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: NARS asparaginyl-tRNA synthetase [ Homo sapiens (human) ]
• Official Symbol: NARS
• Synonyms: NARS; asparaginyl-tRNA synthetase; asparagine--tRNA ligase, cytoplasmic; asparagine tRNA ligase 1; cytoplasmic; NARS1; asparagine tRNA ligase 1, cytoplasmic; asparaginyl-tRNA synthetase, cytoplasmic; ASNRS
• Gene ID: 4677
• mRNA Refseq: NM_004539
• Protein Refseq: NP_004530
• MIM: 108410
• UniProt ID: O43776